First total synthesis of (+)-Carainterol A
โ Scribed by Kaiqing Ma; Chunbo Zhang; Mingming Liu; Yong Chu; Lu Zhou; Changqi Hu; Deyong Ye
- Book ID
- 104097442
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 387 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The first, stereospecific, and elegant synthesis of the natural product (+)-Carainterol A was developed by using the Robinson annulation reaction as a key step to build the eudesmane skeleton.
๐ SIMILAR VOLUMES
A tricyclic sesquiterpenoid, valeriananoid A 1, has been synthesized via domino Michael reaction of oxophorone 4 and subsequent 6-endo-trig cyclization of a ketyl radical as key steps.
A simple and highly efficient first total synthesis of cytotoxic (+)-crassalactone A starting from (R)-mandelic acid is described. The strategy involves the osmium tetroxide-catalyzed cis-hydroxylation and the stereoselective addition of ethyl lithiopropiolate to a chiral aldehyde intermediate as ke