Three selectively labeled propynes were prepared either with deuterium or carbon-13 at position 3 and doubly labeled with carbon-13 at positions 1 and 2 by an alkylation reaction from the corresponding labeled or unlabeled monolithio acetylides and dimethylsulfates. Their lithiation with nBuLi gave
First synthesis of mitomycins completely labeled at the C-6-methyl by 13CH3 and CD3
β Scribed by Arai, Hitoshi; Kanda, Yutaka; Kasai, Masaji
- Book ID
- 127118382
- Publisher
- American Chemical Society
- Year
- 1993
- Tongue
- English
- Weight
- 786 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0022-3263
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The compound 6-chloro-2,3,4,5-tetrahydroi~-methyl-l &3-t#nzazepine (SK&F 86466) was prepared in phenyl-U-C and phenyl-C , labeled forms in a six step sequence beginning with the appropriately labeled benzenes. In addition, the N-desmeJhyl analog of the carbon-1 4 labeled isotopomer and the N-methyl-
## Abstract The title compound (10) has been synthesized from allβEβ2,7β dimethyloctaβ2,4,6βtrieneβ1,8βdial (C~10~βdialdehyde, 8) labelled with four ^13^C from commercially available and relatively inexpensive starting materials. The key starting material in this synthesis, (EtO)~2~P(O)^13^CHMe^13^