First syntheses of the biologically active fungal metabolites pestalotiopsones A, B, C and F
โ Scribed by Beekman, Andrew Michael; Castillo Martinez, Edwin; Barrow, Russell Allan
- Book ID
- 118747398
- Publisher
- Royal Society of Chemistry
- Year
- 2013
- Tongue
- English
- Weight
- 250 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1477-0520
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๐ SIMILAR VOLUMES
## Abstract The epoxyquinone natural products SDEF 678 metabolite, speciosin A, speciosin B and speciosin C have been prepared for the first time via a short synthetic route based around the palladiumโcatalysed coupling of a halogenโsubstituted 1,4โbenzoquinone monoketal, a DielsโAlder/retroโDielsโ
The unchlonnated precursor 4 of CGA 80000 (lJ was synthestzed enanhoselecttvely by two conceptionally dtffetent routes a) by a "choral pool" approach stamng from L-mahc acid and b) by enanttoselecttve hydrogenahon of an enamlde mtemediate. catalyzed by chual Rh-or Ru-phosphme-complexes CGA SO000 Q)
Following our recent total synthesis of the biologically potent natural products otteliones A and B in racemic form, we have now accomplished the total synthesis of both the enantiomers of otteliones A and B through an enantiodivergent strategy emanating from the readily available Diels-Alder adduct