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Enantioselective total syntheses of (+)- and (−)-ottelione A and (+)- and (−)-ottelione B. Absolute configuration of the novel, biologically active natural products

✍ Scribed by Goverdhan Mehta; Kabirul Islam

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
208 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

Following our recent total synthesis of the biologically potent natural products otteliones A and B in racemic form, we have now accomplished the total synthesis of both the enantiomers of otteliones A and B through an enantiodivergent strategy emanating from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone. These endeavors have led to the elucidation of the absolute configuration of naturally occurring otteliones A and B.

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