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First-pass metabolism of cyclosporine a in human intestine: inhibition by diltiazem

โœ Scribed by J.G Preuner; K Lehle; H Eichinger; L Rupprecht

Book ID
117236557
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
126 KB
Volume
30
Category
Article
ISSN
0041-1345

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Differentiation of absorption and first-
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โœ Wu, Chi-Yuan; Benet, Leslie Z.; Hebert, Mary F.; Gupta, Suneel K.; Rowland, Malc ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 604 KB

The low and variable bioavailability of cyclosporine has been attributed to poor absorption. However, recent studies have suggested that intestinal first-pass metabolism exerts a significant effect on bioavailability. We describe theory and methods to differentiate the contribution from oral absorpt