Differentiation of absorption and first-
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Wu, Chi-Yuan; Benet, Leslie Z.; Hebert, Mary F.; Gupta, Suneel K.; Rowland, Malc
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Article
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1995
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Nature Publishing Group
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English
โ 604 KB
The low and variable bioavailability of cyclosporine has been attributed to poor absorption. However, recent studies have suggested that intestinal first-pass metabolism exerts a significant effect on bioavailability. We describe theory and methods to differentiate the contribution from oral absorpt