The low and variable bioavailability of cyclosporine has been attributed to poor absorption. However, recent studies have suggested that intestinal first-pass metabolism exerts a significant effect on bioavailability. We describe theory and methods to differentiate the contribution from oral absorpt
A pharmacokinetic model to differentiate preabsorptive, gut epithelial, and hepatic first-pass metabolism
โ Scribed by Wayne A. Colburn
- Book ID
- 112473648
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 469 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1573-8744
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