𝔖 Bobbio Scriptorium
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First pass effect of pinazepam in the rabbit liver

✍ Scribed by G. M. Pacifici; G. F. Placidi

Book ID
113005909
Publisher
Springer-Verlag
Year
1982
Tongue
English
Weight
469 KB
Volume
7
Category
Article
ISSN
0378-7966

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To assess avoidance of hepatic first-pass effect of drugs, we undertook in situ experiments using rectal administration of lidocaine in the rabbit. We also employed in situ duodenal route to estimate first-pass metabolism across the gastrointestinal mucosa. Rabbits were administered lidocaine HCl in