Oral absorption and presystemic first-pass effect of chlorpheniramine in rabbits
โ Scribed by Shiew-Mei Huang; Yih-Chain Huang; Win L. Chiou
- Book ID
- 112475428
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 686 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1573-8744
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The purpose of this study was to characterize the pharmacokinetics and dose proportionality of the prokinetic macrolide, EM574, in rabbits following intravenous dosing, and to determine the intestinal absorption and intestinal and hepatic ยฎrst-pass elimination of EM574 in rabbits. Two doses (0.05 an