First Dual Aromatase-Steroid Sulfatase Inhibitors
✍ Scribed by Woo, L. W. Lawrence; Sutcliffe, Oliver B.; Bubert, Christian; Grasso, Anna; Chander, Surinder K.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
- Book ID
- 115463095
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 76 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-2623
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Concurrent inhibition of aromatase and steroid sulfatase (STS) may provide a more effective treatment for hormone-dependent breast cancer than monotherapy against individual enzymes, and several dual aromatase–sulfatase inhibitors (DASIs) have been reported. Three aromatase inhibitors with sub-nanom
## Abstract Steroid sulfatase (STS) regulates the local production of estrogens and androgens from systemic precursors in several tissues. The enzyme catalyzes the hydrolysis of the sulfate esters of 3‐hydroxy steroids, which are inactive transport or precursor forms of the active 3‐hydroxy steroid