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Chiral Aromatase and Dual Aromatase−Steroid Sulfatase Inhibitors from the Letrozole Template: Synthesis, Absolute Configuration, and In Vitro Activity†

✍ Scribed by Wood, Paul M.; Woo, L. W. Lawrence; Labrosse, Jean-Robert; Trusselle, Melanie N.; Abbate, Sergio; Longhi, Giovanna; Castiglioni, Ettore; Lebon, France; Purohit, Atul; Reed, Michael J.


Book ID
111980143
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
632 KB
Volume
51
Category
Article
ISSN
0022-2623

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Aromatase and Dual Aromatase-Steroid Sul
✍ Dr. Paul M. Wood; Dr. L. W. Lawrence Woo; Dr. Mark P. Thomas; Dr. Mary F. Mahon; 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 922 KB

Concurrent inhibition of aromatase and steroid sulfatase (STS) may provide a more effective treatment for hormone-dependent breast cancer than monotherapy against individual enzymes, and several dual aromatase–sulfatase inhibitors (DASIs) have been reported. Three aromatase inhibitors with sub-nanom