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Fibrotic scar formed in the lesion site of the central nervous system. I. Impediment for axonal regeneration

✍ Scribed by Kawano, Hitoshi; Kimura-Kuroda, Junko; Yoshioka, Nozomu; Komuta, Yukari; Sango, Kazunori; Kawamura, Koki


Book ID
122530465
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
87 KB
Volume
68
Category
Article
ISSN
0168-0102

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## Abstract Reactive astrocytes are one of the main impediments for axonal regeneration in the central nervous system of mammals. Using mice KO for GFAP and vimentin, we show that reinnervation occurs after an hemisection of the spinal cord, mainly through sprouting of controlateral intact serotoni