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Astrocytes as support for axonal regeneration in the central nervous system of mammals

✍ Scribed by A. Privat

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
43 KB
Volume
43
Category
Article
ISSN
0894-1491

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✦ Synopsis

Abstract

Reactive astrocytes are one of the main impediments for axonal regeneration in the central nervous system of mammals. Using mice KO for GFAP and vimentin, we show that reinnervation occurs after an hemisection of the spinal cord, mainly through sprouting of controlateral intact serotoninergic and cortico‐spinal axons, thanks to the absence of glial reactivity. This reinnervation is paralleled by the restoration of impaired locomotion of the ipselateral hindleg. Future applications to spinal cord injured patients are discussed. GLIA 43:91–93, 2003. Β© 2003 Wiley‐Liss, Inc.

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