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Fibrogenic structure-activity study of the bleomycin molecule

✍ Scribed by Robert A. Newman; Miles P. Hacker; Ted T. Sakai

Book ID
113206069
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
754 KB
Volume
70
Category
Article
ISSN
0041-008X

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A synthetic model for the metal binding site of bleomycin with a 4-methoxypyridine nucleus and a tert-butyl group is shown to be comparable to bleomycin interms of dioxygen activation. This model ligand is coupled with a DNA affinity moiety, tetrapeptide S, to afford a mandesigned bleomycin which e