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Transition-metal binding site of bleomycin. A remarkably efficient dioxygen-activating molecule based on bleomycin-Fe(II) complex

โœ Scribed by Atsushi Kittaka; Yuichi Sugano; Masami Otsuka; Masaji Ohno; Yukio Sugiura; Hamao Umezawa


Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
217 KB
Volume
27
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES


Man-designed bleomycins. synthesis of di
โœ Atsushi Kittaka; Yuichi Sugano; Masami Otsuka; Masaji Ohno ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 916 KB

A synthetic model for the metal binding site of bleomycin with a 4-methoxypyridine nucleus and a tert-butyl group is shown to be comparable to bleomycin interms of dioxygen activation. This model ligand is coupled with a DNA affinity moiety, tetrapeptide S, to afford a mandesigned bleomycin which e

Synthetic models for the transition meta
โœ Atsushi Kittaka; Yuichi Sugano; Masami Otsuka; Masaji Ohno ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 690 KB

Model compounds for the metal binding site of bleomycin with a CH2CONH group (PYML-3) or a tert-butyl group (PYML-4) as stegic environmental factors are synthesized. These exhibit metal binding properties similar to those of bleomycin. In particular, PYML-4 shows oxygen activation up to 71 % of th