A synthetic model for the metal binding site of bleomycin with a 4-methoxypyridine nucleus and a tert-butyl group is shown to be comparable to bleomycin interms of dioxygen activation. This model ligand is coupled with a DNA affinity moiety, tetrapeptide S, to afford a mandesigned bleomycin which e
โฆ LIBER โฆ
Transition-metal binding site of bleomycin. A remarkably efficient dioxygen-activating molecule based on bleomycin-Fe(II) complex
โ Scribed by Atsushi Kittaka; Yuichi Sugano; Masami Otsuka; Masaji Ohno; Yukio Sugiura; Hamao Umezawa
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 217 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Man-designed bleomycins. synthesis of di
โ
Atsushi Kittaka; Yuichi Sugano; Masami Otsuka; Masaji Ohno
๐
Article
๐
1988
๐
Elsevier Science
๐
French
โ 916 KB
Synthetic models for the transition meta
โ
Atsushi Kittaka; Yuichi Sugano; Masami Otsuka; Masaji Ohno
๐
Article
๐
1988
๐
Elsevier Science
๐
French
โ 690 KB
Model compounds for the metal binding site of bleomycin with a CH2CONH group (PYML-3) or a tert-butyl group (PYML-4) as stegic environmental factors are synthesized. These exhibit metal binding properties similar to those of bleomycin. In particular, PYML-4 shows oxygen activation up to 71 % of th