Synthetic models for the transition metal binding site of bleomycin. Remarkable improvement of dioxygen activating capability

✍ Scribed by Atsushi Kittaka; Yuichi Sugano; Masami Otsuka; Masaji Ohno

• Publisher: Elsevier Science
• Year: 1988
• Tongue: French
• Weight: 690 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(88)90017-8

✦ Synopsis

Model compounds for the metal binding site of bleomycin with a CH2CONH group (PYML-3) or a tert-butyl group (PYML-4) as stegic environmental factors are synthesized.

These exhibit metal binding properties similar to those of bleomycin.

In particular, PYML-4 shows oxygen activation up to 71 % of that of bleomycin.