✦ LIBER ✦

Synthetic study towards man-designed bleomycins. Synthesis of a DNA cleaving molecule based on bleomycin.

✍ Scribed by Masami Otsuka; Atsushi Kittaka; Masaji Ohno; Tadashi Suzuki; June Kuwahara; Yukio Sugiura; Hamao Umezawa

Publisher: Elsevier Science
Year: 1986
Tongue: French
Weight: 377 KB
Volume: 27
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)84869-8

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Man-designed bleomycins. synthesis of di

Man-designed bleomycins. synthesis of dioxygen activating molecules and a DNA cleaving molecule based on bleomycin-Fe(II)-02 complex

✍ Atsushi Kittaka; Yuichi Sugano; Masami Otsuka; Masaji Ohno 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 916 KB

A synthetic model for the metal binding site of bleomycin with a 4-methoxypyridine nucleus and a tert-butyl group is shown to be comparable to bleomycin interms of dioxygen activation. This model ligand is coupled with a DNA affinity moiety, tetrapeptide S, to afford a mandesigned bleomycin which e

Metal-complexing, DNA-binding and DNA-cl

Metal-complexing, DNA-binding and DNA-cleaving properties of a synthetic molecule AMBIGLU, a simplified model for the study of bleomycin

✍ Abderraouf Kenani; Christian Bailly; Nicole Helbecque; Raymond Houssin; Jean-Luc 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 915 KB