Fibrillin controls TGF-β activation
✍ Scribed by Kaartinen, Vesa; Warburton, David
- Book ID
- 109915270
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 102 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1061-4036
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Platelets are a major source of transforming growth factor-beta1 (TGF-beta1) in the circulation as they release latent growth factor in response to activation. We report here that human platelets, when stimulated with thrombin, activated a significant proportion of the latent TGF-beta released. Late
## Abstract This article focuses on recent findings that the type V TGF‐β receptor (TβR‐V), which co‐expresses with other TGF‐β receptors (TβR‐I, TβR‐II, and TβR‐III) in all normal cell types studied, is involved in growth inhibition by IGFBP‐3 and TGF‐β and that TGF‐β activity is regulated by two