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BMP1 controls TGFβ 1 activation via cleavage of LTBP

✍ Scribed by G. Ge; D.S. Greenspan

Book ID
116729585
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
59 KB
Volume
25
Category
Article
ISSN
0945-053X

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Growth plate chondrocytes make TGF-␤1 in latent form (LTGF-␤1) and store it in the extracellular matrix via LTGF-␤1 binding protein (LTBP1). 1,25-(OH) 2 D 3 (1,25) regulates matrix protein production in growth zone (GC) chondrocyte cultures, whereas 24,25-(OH) 2 D 3 (24,25) does so in resting zone (