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Latent TGF-β binding proteins (LTBPs) 1 and 3 differentially regulate transforming growth factor-β activity in malignant mesothelioma

✍ Scribed by Piia Vehviläinen; Katri Koli; Marjukka Myllärniemi; Pamela Lindholm; Ylermi Soini; Kaisa Salmenkivi; Vuokko L. Kinnula; Jorma Keski-Oja


Book ID
116534884
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
880 KB
Volume
42
Category
Article
ISSN
1532-8392

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## Abstract The latent TGF‐β binding protein (LTBP)‐3 is an extracellular matrix (ECM) protein that binds the small latent complex (SLC) of TGF‐β. Disruption of the __Ltbp‐3__ gene by homologous recombination in mice yields mutant animals that display multiple skeletal abnormalities. In addition, t