Platelets are a major source of transforming growth factor-beta1 (TGF-beta1) in the circulation as they release latent growth factor in response to activation. We report here that human platelets, when stimulated with thrombin, activated a significant proportion of the latent TGF-beta released. Late
✦ LIBER ✦
TGF-β activation by traction?
✍ Scribed by Jorma Keski-Oja; Katri Koli; Harald von Melchner
- Book ID
- 113925381
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 246 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0962-8924
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## Abstract Transforming growth factor‐β (TGF‐β) responsiveness in cultured cells can be modulated by TGF‐β partitioning between lipid raft/caveolae‐ and clathrin‐mediated endocytosis pathways. The TβR‐II/TβR‐I binding ratio of TGF‐β on the cell surface has recently been found to be a signal that c
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