𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Fibrates suppress bile acid synthesis via PPARα-mediated down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase gene expression

✍ Scribed by S.M. Post; B. Staels; E. de Fabiani; J.Y.L. Chiang; H.M.G. Princen; M. Crestani

Book ID
119438879
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
144 KB
Volume
144
Category
Article
ISSN
0021-9150

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Regulation of bile acid synthesis by deo
Regulation of bile acid synthesis by deoxycholic acid in the rat: Different effects on cholesterol 7α-hydroxylase and sterol 27-hydroxylase
✍ Sarah Shefer; Betsy T. Kren; Gerald Salen; Clifford J. Steer; Lien B. Nguyen; Th 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 982 KB

We examined the effects of feeding deoxycholic acid (1% and 0.4% of diet), alone and in combination with ursodeoxycholic acid, on serum and biliary bile acid concentrations, hepatic morphology, and the activities and steady-state messenger RNA (mRNA) levels of HMG-CoA reductase and cholesterol 7a-hy

Glucagon and cAMP inhibit cholesterol 7α
Glucagon and cAMP inhibit cholesterol 7α-hydroxylase (CYP7a1) gene expression in human hepatocytes: Discordant regulation of bile acid synthesis and gluconeogenesis
✍ Kwang-Hoon Song; John Y. L. Chiang 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 478 KB

The gene encoding cholesterol 7␣-hydroxylase (CYP7A1) is tightly regulated to control bile acid synthesis and maintain lipid homeostasis. Recent studies in mice suggest that bile acid synthesis is regulated by the fasted-to-fed cycle, and fasting induces CYP7A1 gene expression in parallel to the ind