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Fetal cells of mesenchymal origin in cultures derived from synovial tissue and skin of patients with rheumatoid arthritis

✍ Scribed by Ilona Hromadnikova; Denisa Zlacka; Thi Thu Hien Nguyen; Lucie Sedlackova; Lenka Zejskova; Antonin Sosna


Book ID
113684515
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
127 KB
Volume
75
Category
Article
ISSN
1297-319X

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Cytogenetic analysis of primary cell cultures and/or passages 1-3 of synovial tissue from seven patients with rheumatoid arthritis was performed. As the only recurrent chromosome aberration, trisomy 7 was found in six of seven cultures. In four cultures, trisomy 7 occurred as a clonal change in up t

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## Abstract Markedly elevated levels of T cells expressing Ia antigens were found in the synovial membranes and synovial fluids of patients with rheumatoid arthritis. The primary increase in expression of the la antigens was on the OKT 8+ (suppressor/cytotoxic) T cell subset. In addition, the total