Clonal chromosome aberrations in cell cultures of synovial tissue from patients with rheumatoid arthritis

✍ Scribed by Ayhan Ermis; Thomas Hopf; Rainer Hanselmann; Klaus Remberger; Cornelius Welter; Steven Dooley; Klaus D. Zang; Wolfram Henn

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 269 KB
• Volume: 6
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870060407

✦ Synopsis

Cytogenetic analysis of primary cell cultures and/or passages 1-3 of synovial tissue from seven patients with rheumatoid arthritis was performed. As the only recurrent chromosome aberration, trisomy 7 was found in six of seven cultures. In four cultures, trisomy 7 occurred as a clonal change in up to 20% of the analyzed cells, with an increase of the proportion of cells with + 7 with the duration of the in vitro culture. Apart from this recurrent change, a variety of partly clonal, partly nonclonal numerical and structural chromosome aberrations were observed in all cases. These findings support the view that clonal chromosome aberrations may play a role in the pathogenesis of invasive growth of the synovial tissue in rheumatoid arthritis although the localized synovial hyperproliferation is not a true neoplastic process. Genes Chrorn Cancer 6:232-234 ( I 993).