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Studies of serum immunoglobulin binding to synovial fibroblast cell cultures from patients with rheumatoid arthritis

✍ Scribed by William B. Gruhn; Frederic C. Mcduffie


Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
569 KB
Volume
23
Category
Article
ISSN
0004-3591

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Cytogenetic analysis of primary cell cultures and/or passages 1-3 of synovial tissue from seven patients with rheumatoid arthritis was performed. As the only recurrent chromosome aberration, trisomy 7 was found in six of seven cultures. In four cultures, trisomy 7 occurred as a clonal change in up t

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## Abstract ## Objective To study the regulation of interleukin‐18 binding protein (IL‐18BP) production by rheumatoid arthritis (RA) or control peripheral blood mononuclear cells (PBMCs) and by RA synovial tissue cells, and to compare the levels of IL‐18BP messenger RNA (mRNA) expression in whole