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Fertility and pregnancy in women with familial adenomatous polyposis

✍ Scribed by C. Johansen; M. Bitsch; S. Bülow

Book ID
104714160
Publisher
Springer
Year
1990
Tongue
English
Weight
362 KB
Volume
5
Category
Article
ISSN
0179-1958

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✦ Synopsis

A questionnaire study was carried out among 58 Danish women with familial adenomatous polyposis concerning fertility, pregnancies, abortions and deliveries. Further data were obtained from obstetric records and general practitioners. The fertility and the course of the pregnancy of women with polyposis, frequency of miscarriages, legal abortions, mature and premature infants corresponds to the frequency among the obstetric population in Denmark. Of the 73 infants, eight (11%) were delivered by caesarean section. Of the 16 women who gave birth after an operation for familial adenomatous polyposis, 5 (31%) had a caesarean section. Of the seven infants who died, two had lethal congenital malformations and three infants were very premature.

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Familial adenomatous polyposis (FAP) represents a human model of the adenomasarcinoma sequence. Colectomy substantially reduces the cancer risk. Restorative proctocolectomy maintains continence and abolishes the risk of rectal cancer, but there is a price to pay in terms of an increased morbidity ra