Ferrocenylsubstituted α,β-unsaturated ketones in the synthesis of dihydropyrimidinethiones
✍ Scribed by Vyacheslav N. Postnov; Alexander V. Goncharov; Ines Hocke; Dmitry P. Krut'ko
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 234 KB
- Volume
- 456
- Category
- Article
- ISSN
- 0022-328X
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The title compounds are synthesized in one-pot from the easily available sodium salts of unsymmetrical 1,3\_dicarbonyl derivatives and chiral alkoxides. Die&.-Alder additions still play a major role in preparative organic chemistry and asymmetric induction in such reactions represents a challenge i
Selective bromination of a&unsaturated ketones has been achieved by the action of 2,4,4,6tetrabromocyclohexa-2$dienone. The stereochemistry, conformation and relative stability of the bromination products of some steroidic unsaturated ketones have been also determined.
An efficient synthesis of d +-unsaturated ketones based on reaction of alkenylcopper(l)reagents with selenoesters (or acylchlorides) has bee11 elaborated.