Ferrocene—Peptide Bioconjugates
✍ Scribed by Toshiyuki Moriuchi; Toshikazu Hirao
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 11 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The grafting‐to of a peptide to a side chain functional polymer was investigated using “click” chemistry. Two click reactions were compared: the copper‐free strain‐promoted azide‐alkyne 1,3‐cycloaddition (SPAAC) and the traditional copper‐catalyzed azide‐alkyne 1,3‐cycloaddition (CuAAC)
## Abstract Ferrocene‐containing dipeptides Ac‐Fca‐AA‐OMe (AA = L‐Val, L‐Ile) with the artificial amino acid 1'‐aminoferrocene‐1‐carboxylic acid (Fca) and chiral α‐amino acid building blocks display hydrogen‐bonded structures that result in organised helical ferrocene units in solution, as evidence
an der Ruhr (Germany) [\*\*] This work is supported by the German Research Foundation (DFG) through funding of a Research Unit "Biological Function of Organometallic Compounds" (FOR 630). Synthesis and partial chemical characterization of the conjugates was carried out at the Institute of Pharmacy a