✦ LIBER ✦

Femtogram level quantitative determination of nitroglycerin and metabolites in human plasma by GC-MS negative ion chemical ionization, single ion monitoring

✍ Scribed by Settlage, J. A. ;Gielsdorf, W. ;Jaeger, H.

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 362 KB
Volume: 6
Category: Article
ISSN: 0935-6304
DOI: 10.1002/jhrc.1240060204

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Recent developments in the use of negative ion detection in GC‐MS have indicated the potential for highly sensitive analyses for certain compounds. This paper describes the application of the techniques to the assay of Nitroglycerin and its metabolites yielding sensitivity to two femtograms. Because of the low levels of nitroglycerin in biological media such sensitivity is highly desirable if not essential for meaningful measurements. In addition to sensitivity the method is shown to yield extremely good selectivity contributing further to the credibility of quantitative results.

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