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Quantitative determination of nitroglycerin in human plasma by capillary gas chromatography negative ion chemical ionization mass spectrometry

✍ Scribed by Pekka Ottoila; Jyrki Taskinen; Aslak Sothmann

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
265 KB
Volume
9
Category
Article
ISSN
1076-5174

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✦ Synopsis

A quantitative method for determination of nitroglycerin in human plasma was developed. Nitroglycerin and the internal standard (butane-1,2,4-triyl trinitrate) were extracted from plasma with pentane. The extracts were analysed by gas chromatography mass spectrometry using fused silica capillary columns and electron capture negative ion chemical ionization. The quantitation limit of the method was about 50 pg m1-l. Linear calibration curves were obtained in the range of 50-1600 pg m1-l. Precision at the level of 100 pg ml-' was 4%.

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