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Deuterium-labelling and quantitative measurement of Ketotifen in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry

✍ Scribed by Hans Jörg Leis; Ernst Malle

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
217 KB
Volume
20
Category
Article
ISSN
1076-5174

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✦ Synopsis

A gas chromatographic/mass spectrometric assay for the anti-anaphylactic agent Ketotifen is described. The method is based on negative ion chemical ionization, utilizing the electrophoric nature of the underivatized drug. A simple procedure for deuteration of the intact target molecule is presented, thus enhancing specificity by internal standardization via stable isotope dilution. The assay was applied to pharmacokinetics of the drug in man.

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