✦ LIBER ✦

Features: Volume 111, Number 2

Book ID: 102877104
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 601 KB
Volume: 111
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.22903

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✦ Synopsis

VOLUME 111 • NUMBER 2

FEATURES

Adult stem cells have gained signifi cant attention in regenerative medicine in recent years. Ethical issues regarding use of embryonic stem cells and frequent teratoma formation have contributed to their popularity. In particular, bone marrow-derived mesenchymal stem cells (MSCs) appear to be highly effi cacious for the regeneration of damaged skeletal and cartilageneous tissues in osteoporosis, osteogenesis imperfecta, osteoarthritis and osteolytic bone metastasis. The multipotent nature of MSCs has also been established recently, which might extend its application in tissue regeneration beyond mesodermal lineages. Additionally, the immunoprivileged nature of MSCs allows implantation of allogeneic donor MSC to patients with different HLA types without rejection by the host immune system. Homing of MSCs to injury sites, including solid tumors, led to their use in targeted cancer therapeutics with signifi cant success. However, caution should be applied as MSCs have been reported to develop sarcomas in ex vivo cultures in a few occasions. Additionally, during their propagation in culture they undergo physical and molecular changes which may affect their homing and regenerative potential. In this review article, Chanda et al discuss the current status of MSC-based therapeutics in skeletal defects

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