Limbal stem cell defi ciency is a painful and blinding disease which affects the cornea at the front of the eye. 13 years have now elapsed since cultured cell therapy was fi rst used to successfully treat patients with this debilitating disease. The clinical application of this laboratory based tech
Features: Volume 112, Number 2
- Book ID
- 102303824
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 98 KB
- Volume
- 112
- Category
- Article
- ISSN
- 0730-2312
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โฆ Synopsis
Stem and progenitor cells from a variety of sources may provide effective treatments for regenerative medicine. In their prospect, Shimada and Spees review current issues and hurdles facing cell-based treatments for diseased and injured neurological tissues. Several questions are addressed: Are stem/progenitor cells ready for clinical application? What types of stem or progenitor cells should be used for particular treatments? What therapies may lead to tumor formation after cell transplantation? Are the benefi ts of cell transplantation occurring through direct cell replacement or paracrine effects? The paracrine biology of stem/progenitor cells is discussed as an exciting opportunity to identify combinations of proteins and peptides that can be used to rescue and/or repair tissue after injury.
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