𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Fast and efficient synthesis of 14C labelled benzonitriles and their corresponding acids

✍ Scribed by Søren Christian Schou

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
122 KB
Volume
52
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

^14^C‐Anthranilic acid has been prepared in a fast and efficient way in a two‐step reaction in 82% overall radiochemical yield. Thus, 2‐iodoaniline was transformed into 2‐amino‐[7‐^14^C]‐benzonitrile using a palladium catalyzed cyanation with zinc ^14^C‐cyanide. Subsequent basic hydrolysis of the cyano group afforded [7‐^14^C]‐anthranilic acid. The method was successfully applied to a benzophenone scaffold, 4‐iodophenol and 4‐iodobenzoic acid producing the corresponding carboxylic acids in good to excellent radiochemical yields (62–82%) and with high specific activity (1.94–1.98 GBq/mmol). Copyright © 2009 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

A facile and efficient synthesis of 14C-
A facile and efficient synthesis of 14C-labelled sulforaphane
✍ Christopher A. D'Souza; Shantu Amin; Dhimant Desai 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 118 KB

## Abstract Isothiocyanates have gained considerable attention for their role as potent chemopreventive agents. Sulforaphane, **1a** (SFN), a naturally occurring isothiocyanate, was isotopically labelled in five steps starting from 3‐(methylthio)‐1‐propanol (**2**)**.** Reacting **2** with tosyl ch

Synthesis of 13C- and 14C-labeled ellagi
Synthesis of 13C- and 14C-labeled ellagic acid
✍ Nrusingha C. Mishra; Barry Gold 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 572 KB

## Abstract The syntheses of [^13^C]‐ and [^14^C]ellagic acid (EA) were accomplished by reacting [^13^C]‐ or [^14^C]CO~2~ with metalated 3,4,5‐trimethoxybenzene to afford trimethylgallic acid which was O‐demethylated with hydroiodic acid. Oxidation of the resulting labeled gallic acid with potassiu

Synthesis of 13C- and 14C-Labeled methan
Synthesis of 13C- and 14C-Labeled methanesulfinic and methanesulfonic acids
✍ V. J. Feil; J. K. Huwe; D. M. Dulik; C. Fenselaum 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 332 KB

The enzyme catalyzed displacement o f the methyl s u l f o n y l group from pentachlorophenyl methyl sulfone, the pchloroperoxybenzoic a c i d oxidation of methyl mercaptan and the reaction o f m e t h y l l i t h i u n with sulfur dioxide are methods described f o r the synthesis o f i s o t o p i

Synthesis of 14C- and 14C3-labelled Org
Synthesis of 14C- and 14C3-labelled Org 37462
✍ P. H. G. Wiegerinck; L. W. H. Hofstede; F. M. G. M. Sperling; J. F. Vader 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 237 KB 👁 1 views

## Abstract Org 37462 (1) is the active ingredient in Orgalutran^®^, an innovative product that reduces the time of treatment in __in vitro__ fertilization from four to less than two weeks. Org 37462 is a synthetic decapeptide containing several amino acids that are unnatural in stereochemistry and

Synthesis of 13C- and 14C-labelled catec
Synthesis of 13C- and 14C-labelled catechol
✍ Rong Ji; Andreas Schäffer 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 93 KB 👁 1 views

## Abstract ^13^C‐ and ^14^C‐uniformly labelled catechol was synthesized from phenol in three steps. Phenol was derivatized with 2‐chloro‐5‐nitrobenzophenone in THF containing NaH, followed by __ortho__‐hydroxylation with 35% aqueous H~2~O~2~ in sulphuric acid/glacial acetic acid solution, and by c