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Fas single nucleotide polymorphisms and risk of thyroid and salivary gland carcinomas: A case-control analysis

✍ Scribed by Tang Ho; Guojun Li; Chong Zhao; Rong Zheng; Qingyi Wei; Erich M. Sturgis

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 142 KB
Volume: 30
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.20699

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

The purpose of this study was to examine the association between 4 Fas single nucleotide polymorphisms (SNPs) and risk of differentiated thyroid carcinoma (DTC) and salivary gland carcinoma (SGC).

Methods.

We conducted a case‐control study including 279 DTC cases, 165 benign thyroid disease (BTD) cases, 154 SGC cases, 61 benign salivary gland disease (BSGD) cases, and 510 controls.

Results.

The A744G SNP genotype distribution was significantly different between subjects with SGC or BSGD and controls, while that of the A18272G SNP was significantly different between subjects with DTC or SGC and controls. Risk of SGC was significantly elevated for the 22628 heterozygous CT genotype (odds ratio [OR] = 1.5, p = .050), and risk of BSGD was elevated for the 22628 homozygous TT genotype (OR = 2.9, p = .023).

Conclusion.

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