𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: A case-control analysis

✍ Scribed by Ana S. Neumann; Heather J. Lyons; Hongbing Shen; Zhensheng Liu; Qiuling Shi; Erich M. Sturgis; Sanjay Shete; Margaret R. Spitz; Adel El-Naggar; Waun Ki Hong; Qingyi Wei

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
95 KB
Volume
115
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Folate deficiency is implicated in cancer risk that may be modulated by a genetic variation in the methylenetetrahydrofolate reductase (MTHFR) gene in folate metabolism. We hypothesized that genetic variants in MTHFR are associated with risk of squamous cell carcinoma of the head and neck (SCCHN). We genotyped 3 MTHFR polymorphisms (C677T, A1298C and G1793A) and estimated their haplotypes in a hospital‐based case‐control study of 537 SCCHN cases and 545 cancer‐free controls. The controls were frequency‐matched to the cases by age (± 5 years), sex, ethnicity and smoking status. We found that the MTHFR 1298AC/CC genotypes were associated with an approximately 35% reduction in risk of SCCHN (adjusted odds ratio = 0.65; 95% CI = 0.51–0.82) compared to the AA genotype. The MTHFR 677CT and 1793GA/AA genotypes were associated with nonsignificant increased risk of SCCHN compared to the 677CC and 1793GG genotypes, respectively. We estimated that there were 8 haplotypes and 16 haplotype genotypes based on these 3 variants. When we used the haplotypes and assumed that the 677T, 1298A and 1793A alleles were risk alleles, the adjusted odds ratios increased as the number of risk alleles increased: 1.00 for 0–1 variant, 1.85 (1.3–2.5) for any 2 risk alleles and 1.93 (1.4–2.7) for any 3 risk alleles. These results suggest that all 3 MTHFR polymorphisms may play a role in the susceptibility to SCCHN among non‐Hispanic whites. Future studies should incorporate detailed data on alcohol consumption, dietary folate intake and related serologic measurements. © 2005 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Glutathione-S-transferase polymorphisms
Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck
✍ Lie Cheng; Erich M. Sturgis; Susan A. Eicher; David Char; Margaret R. Spitz; Qin 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 106 KB 👁 2 views

Differences in genetic susceptibility to tobacco-induced carcinogenesis appear to modulate an individual's risk of squamous-cell carcinoma of the head and neck (SCCHN). Risk for SCCHN may be associated with the null alleles of the carcinogen-metabolizing genes glutathione-S-transferase (GST) T1 and

A variant of the DNA repair gene XRCC3 a
A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: A case-control analysis
✍ Hongbing Shen; Erich M. Sturgis; Kristina R. Dahlstrom; Yuxin Zheng; Margaret R. 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 101 KB 👁 1 views

## Abstract Individuals differ in their ability to repair DNA damage induced by carcinogens. Studies have shown that polymorphisms in DNA repair genes contribute to individual variation in DNA repair capacity and cancer risk. In a hospital‐based case‐control study, we tested the hypothesis that a C

Outcomes after radiotherapy for basaloid
Outcomes after radiotherapy for basaloid squamous cell carcinoma of the head and neck : A case–control study
✍ Juliette Thariat; Anesa Ahamad; Adel K. El-Naggar; Michelle D. Williams; Floyd C 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 439 KB 👁 1 views

## Abstract ## BACKGROUND. Basaloid squamous cell carcinoma (BSCC) is an uncommon, high‐grade variant of squamous cell carcinoma (SCC) of the head and neck. Its poorer prognosis compared with common SCC remains controversial. The authors investigated the outcomes of patients with BSCC who received

Mutational analysis of the PTEN gene in
Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma
✍ Xiyun Shao; Raj Tandon; Ghassan Samara; Hiroaki Kanki; Hiroko Yano; Lanny G. Clo 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 121 KB 👁 2 views

## Loss of heterozygosity (LOH ) at chromosome band 10q23 occurs frequently in a wide variety of human tumors. A recently identified candidate tumor suppressor gene, PTEN located on 10q23, is mutated in multiple advanced cancers. To explore whether PTEN is associated with human squamous cell carci

Epidemiology of carcinogen metabolism ge
Epidemiology of carcinogen metabolism genes and risk of squamous cell carcinoma of the head and neck
✍ Tang Ho; Qingyi Wei; Erich M. Sturgis 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 370 KB

## Abstract The risk association between tobacco and alcohol use with squamous cell carcinoma of the head and neck (SCCHN) is well recognized. However, clearly not all individuals who smoke or drink develop SCCHN. Individual genetic susceptibility differences in carcinogen‐metabolizing enzyme funct

Survival analysis of head and neck squam
Survival analysis of head and neck squamous cell carcinoma: Influence of smoking and drinking
✍ Farzaneh Farshadpour; Hanneke Kranenborg; Eveline Van Beeck Calkoen; Gerrit Jan 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 175 KB 👁 1 views

## Abstract ## Background. Head and neck squamous cell carcinomas (HNSCCs) are associated with tobacco and alcohol; however, the prognostic relevance of these substances is unclear. ## Methods. Univariate and multivariate survival analyses were performed for patients with (__n__ = 1829) and with