𝔖 Bobbio Scriptorium
✦   LIBER   ✦

XRCC1 gene polymorphisms and esophageal squamous cell carcinoma risk in Chinese population: A meta-analysis of case–control studies

✍ Scribed by Liping Dai; Kaijuan Wang; Jianying Zhang; Quanjun Lv; Xiaobing Wu; Yanping Wang

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
385 KB
Volume
125
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Two non‐synonymous polymorphisms Arg194Trp and Arg399Gln in the DNA‐base excision repair gene X‐ray repair cross‐complementing group 1 (XRCC1) have been implicated in risk for esophageal cancer. However, the results from different studies remain controversial. The present meta‐analysis of literatures was performed to clarify these associations in Chinese population. A comprehensive literature search was conducted to identify all case–control studies of XRCC1 polymorphisms Arg194Trp and Arg399Gln and risk for esophageal squamous cell carcinoma (ESCC). A total of 9 eligible studies, including 1,538 ESCC cases and 2,472 controls, were identified to the meta‐analysis. The odds ratio (OR) for the variant homozygous genotype Trp/Trp of the Arg194Trp polymorphism, compared with the wild‐type homozygote Arg/Arg, was 1.59 (p = 0.0007), with 95% confidence interval (95% CI) 1.22–2.09, for ESCC risk without between‐study heterogeneity. However, there was no statistically significant associations of ESCC risk in the dominant model Arg/Trp+Trp/Trp (OR 0.97; 95% CI 0.84–1.12; p = 0.69) and heterozygous genotype Arg/Trp (OR 0.90; 95% CI 0.77–1.04; p = 0.16) when comparing with wild‐type genotype Arg/Arg. For Arg399Gln, there was no effect in dominant modeling (Arg/Gln+Gln/Gln vs. Arg/Arg: OR 0.92; 95% CI 0.80–1.06; p = 0.25), and the variant Gln/Gln homozygote was not associated with ESCC risk (OR 1.29; 95% CI 0.79–2.10; p = 0.31), either. In conclusion, Arg194Trp genetic polymorphism may be associated with an increased risk for developing ESCC and a study with the larger sample size is needed to further evaluate gene–environment interaction on XRCC1 polymorphisms and ESCC risk. © 2009 UICC

📜 SIMILAR VOLUMES

Polymorphisms of DNA repair genes XRCC1
Polymorphisms of DNA repair genes XRCC1 and XPD and their associations with risk of esophageal squamous cell carcinoma in a Chinese population
✍ Deyin Xing; Jun Qi; Xiaoping Miao; Wenfu Lu; Wen Tan; Dongxin Lin 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 83 KB 👁 2 views

## Abstract Esophageal squamous cell carcinoma (ESCC), which is prevalent in China, is believed to be induced by environmental carcinogens. Accumulating evidence has shown that individual variation in DNA repair capacity resulting from genetic polymorphism influences risk of environmental carcinoge

Polymorphisms in CYP1A1 and breast carci
Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case–control study of Chinese women
✍ Sonia M. Boyapati; Xiao Ou Shu; Yu-Tang Gao; Qiuyin Cai; Fan Jin; Wei Zheng 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 98 KB 👁 1 views

## Abstract ## BACKGROUND Cytochrome P450 1A1 (CYP1A1) is involved in the 2‐hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. ## METHODS The authors evaluated common polymorphisms in the __CYP1A1__ gene in relation to breast carcinoma risk in

A variant of the DNA repair gene XRCC3 a
A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: A case-control analysis
✍ Hongbing Shen; Erich M. Sturgis; Kristina R. Dahlstrom; Yuxin Zheng; Margaret R. 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 101 KB 👁 1 views

## Abstract Individuals differ in their ability to repair DNA damage induced by carcinogens. Studies have shown that polymorphisms in DNA repair genes contribute to individual variation in DNA repair capacity and cancer risk. In a hospital‐based case‐control study, we tested the hypothesis that a C

High frequency of CDKN2A alterations in
High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high-risk Chinese population
✍ Nan Hu; Chaoyu Wang; Hua Su; Wen-Jun Li; Michael R. Emmert-Buck; Guang Li; Mark 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 224 KB

## Abstract Because previous studies have shown that loss of heterozygosity (LOH) is common on chromosome arm 9p in esophageal squamous cell carcinoma (ESCC) and that genetic alterations in __CDKN2A__ and __CDKN2B__ on 9p are also common, we sought to determine whether LOH and these genetic alterat

Methylenetetrahydrofolate reductase poly
Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: A case-control analysis
✍ Ana S. Neumann; Heather J. Lyons; Hongbing Shen; Zhensheng Liu; Qiuling Shi; Eri 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 95 KB

## Abstract Folate deficiency is implicated in cancer risk that may be modulated by a genetic variation in the methylenetetrahydrofolate reductase (MTHFR) gene in folate metabolism. We hypothesized that genetic variants in __MTHFR__ are associated with risk of squamous cell carcinoma of the head an