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Farnesyltransferase inhibition: a novel method of immunomodulation

โœ Scribed by Ming-Sing Si; Ping Ji; Bruce J. Tromberg; Mike Lee; Jennifer Kwok; Shi-Chung Ng; David K. Imagawa

Book ID
117798157
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
221 KB
Volume
3
Category
Article
ISSN
1567-5769

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3-Imidazolylmethylaminophenylsulfonyltet
3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a novel series of farnesyltransferase inhibitors
โœ Charles Z Ding; John T Hunt; Carol Ricca; Veeraswamy Manne ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 108 KB

Design, synthesis and structure-activity relationship of a series of 3-imidazolylmethylaminophenylsulfonyltetrahydroquinolines as farnesyltransferase inhibitors are presented. A working pharmacophore of inhibiting farnesyltransferase by this series of inhibitors is proposed.