3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a novel series of farnesyltransferase inhibitors

✍ Scribed by Charles Z Ding; John T Hunt; Carol Ricca; Veeraswamy Manne

• Book ID: 104364968
• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 108 KB
• Volume: 10
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(99)00686-1

✦ Synopsis

Design, synthesis and structure-activity relationship of a series of 3-imidazolylmethylaminophenylsulfonyltetrahydroquinolines as farnesyltransferase inhibitors are presented. A working pharmacophore of inhibiting farnesyltransferase by this series of inhibitors is proposed.