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Discovery of a New Class of Protein Farnesyltransferase Inhibitors in the Arylthiophene Series

✍ Scribed by Lethu, Sébastien; Ginisty, Maryon; Bosc, Damien; Dubois, Joëlle


Book ID
127194038
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
743 KB
Volume
52
Category
Article
ISSN
0022-2623

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A variety of compounds that show promise in cancer chemotherapy and chemoprevention have been identified as farnesyltransferase inhibitors. These can be classified into mainly two different types of inhibitors, farnesyl diphosphate competitors and CAAX peptidomimetics. The former type acts by compet