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Inhibition of farnesyltransferase with A-176120, a novel and potent farnesyl pyrophosphate analogue

โœ Scribed by S.K Tahir; W.-Z Gu; H.-C Zhang; J Leal; J.Y Lee; P Kovar; B Saeed; S.P Cherian; E Devine; J Cohen; R Warner; Y.-C Wang; D Stout; D.L Arendsen; S Rosenberg; S.-C Ng

Book ID
117656811
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
418 KB
Volume
36
Category
Article
ISSN
0959-8049

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๐Ÿ“œ SIMILAR VOLUMES

A novel approach towards the synthesis o
A novel approach towards the synthesis of pyrophosphate analogues of farnesyl pyrophosphate
โœ A.R.P.M. Valentijn; O. van den Berg; G.A. van der Marel; J.H. van Boom; L.H. Coh ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 415 KB

## Abstract The synthesis of two new analogues (__i.e.__ 3 and 4) of farnesyl pyrophosphate (FPP) containing a phosphonophosphate and a phosphonophosphonate moiety was accomplished via the phosphonomorpholidate. The latter was easily obtained by treatment of a phosphonic chloride with morpholine.