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A novel approach towards the synthesis of pyrophosphate analogues of farnesyl pyrophosphate

✍ Scribed by A.R.P.M. Valentijn; O. van den Berg; G.A. van der Marel; J.H. van Boom; L.H. Cohen

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
415 KB
Volume
113
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

The synthesis of two new analogues (i.e. 3 and 4) of farnesyl pyrophosphate (FPP) containing a phosphonophosphate and a phosphonophosphonate moiety was accomplished via the phosphonomorpholidate. The latter was easily obtained by treatment of a phosphonic chloride with morpholine.

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