Farnesyl-Derived Inhibitors of ras Farnesyl Transferase
β Scribed by M.S. Kang; D.M. Stemerick; J.H. Zwolshen; B.S. Harry; P.S. Sunkara; B.L. Harrison
- Book ID
- 115577687
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 216 KB
- Volume
- 217
- Category
- Article
- ISSN
- 0006-291X
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## Abstract The synthesis of __ras__ farnesylβprotein transferase inhibitor **1** is described on a multiβkilogram scale. Retrosynthetic analysis reveals chloromethylimidazole **2** and a piperazinone **3** as viable precursors. The 1,5βdisubstituted imidazole system was regioselectively assembled