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Family studies: The key to understanding the genetic and environmental etiology of chronic disease?

✍ Scribed by Dr. Janice S. Dorman; Massimo Trucco; Ronald E. LaPorte; Lewis H. Kuller

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 442 KB
Volume: 5
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370050502

No coin nor oath required. For personal study only.

✦ Synopsis

The role of genetic epidemiology in chronic disease research has, since the foundation of the field, varied considerably and has generally reflected the principles of either human genetics or epidemiology rather than a truly combined genetic epidemiologic approach. For example, methods employed in population genetics [Vogel and Motulsky, 1979; Li, 19781, such as segregation, linkage, and pedigree analyses, have been applied to evaluate the genetic susceptibility to chronic disease. Although these studies of families have contributed greatly to our understanding of the modes of inheritance of chronic diseases, they have not, in general, accounted for the roles of nongenetic risk factors in the etiology of these conditions. As a result, methodologic approaches designed specifically to incorporate environmental indices,

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