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The genetics of Crohn disease: Complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives

✍ Scribed by Küster, Wolfgang ;Pascoe, Leigh ;Purrmann, Jochen ;Funk, Sabine ;Majewski, Frank ;Opitz, John M. ;Reynolds, James F.

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 397 KB
Volume: 32
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.1320320122

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✦ Synopsis

We have analysed the pedigrees of 265 probands with Crohn disease, collected from a specialty clinic at the University of Dusseldorf. Complex segregation analysis suggests the presence of a recessive gene with incomplete penetrance for susceptibility to the disease with no residual causes of family resemblance. However, a proportion of the isolated cases are probably due to phenocopies, this proportion being greatest among cases with an advanced age of onset.

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