Factors influencing sister-chromatid exchange rate in cultured human lymphocytes
β Scribed by William F. Morgan; Peter E. Crossen
- Book ID
- 113192067
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 453 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0027-5107
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The number of sister chromatid exchanges (SCE) per metaphase was determined in normal human lymphocytes by the Hoechst-Giemsa procedure. UV C irradiation promotes SCE dose-dependent in the range of 0-40 mJ/cm2. No difference of this phenomenon may be observed, compairing young volunteers (20-40 year
This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m