✦ LIBER ✦

Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma

✍ Scribed by Simon R. Best; Patrick K. Ha; Ray G. Blanco; John R. Saunders Jr.; Eva S. Zinreich; Marshall A. Levine; Sara I. Pai; Melissa Walker; Jaclyn Trachta; Karen Ulmer; Peter Murakami; Richard Thompson; Joseph A. Califano; Barbara P. Messing

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 225 KB
Volume: 33
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21657

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

The purpose of this study was to elucidate factors associated with pharyngoesophageal strictures after treatment for head and neck squamous cell carcinoma (SCC).

Methods

We conducted a retrospective review of patients receiving cisplatin and 5‐fluorouracil chemotherapy combined with concurrent hyperfractionated radiation therapy for oropharyngeal squamous cell carcinoma.

Results

Strictures developed in 13 of 67 patients (19%). Strictures were associated with tumor location (tonsil vs base of tongue; p = .03), neck dissection after completion of therapy (p = .03), and the duration of treatment‐induced mucositis (weeks with mucositis grade ≥2; National Cancer Institute (NCI) Common Toxicity Criteria; p < .001). Age, sex, race, tumor stage, nodal stage, American Joint Committee on Cancer (AJCC) stage, human papillomavirus (HPV) status, smoking, radiation dose, maximum severity of mucositis, amifostine use, and pretreatment swallow dysfunction were not significantly associated with stricture. In multivariate analysis, only duration of mucositis, after controlling for age, sex, and tumor location, remained highly significant (p < .01).

Conclusion

The duration of treatment‐related mucositis is an independent risk factor for stricture formation in patients with oropharyngeal SCC treated with concurrent chemotherapy and radiation therapy. © 2011 Wiley Periodicals, Inc. Head Neck, 2011

📜 SIMILAR VOLUMES

Neoadjuvant chemotherapy/gefitinib follo

Neoadjuvant chemotherapy/gefitinib followed by concurrent chemotherapy/radiation therapy/gefitinib for patients with locally advanced squamous carcinoma of the head and neck

✍ John D. Hainsworth; David R. Spigel; Howard A. Burris III; Tiffanie M. Markus; D 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 228 KB 👁 1 views

Clinical prognostic factors in patients

Clinical prognostic factors in patients with locally advanced (stage III) nonsmall cell lung cancer treated with hyperfractionated radiation therapy with and without concurrent chemotherapy : Single-Institution Experience in 600 Patients

✍ Branislav Jeremić; Biljana Miličić; Slobodan Milisavljevic 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 138 KB 👁 2 views

Concurrent chemotherapy with intensity-m

Concurrent chemotherapy with intensity-modulated radiation therapy for locally advanced squamous cell carcinoma of the larynx and oropharynx: A retrospective single-institution analysis

✍ Nabil F. Saba; Scott Edelman; Mourad Tighiouart; Jennifer Gaultney; Lawrence W. 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 240 KB 👁 1 views

## Abstract ## Background We present outcome data from concurrent chemotherapy and intensity‐modulated radiation therapy (IMRT) for squamous cell carcinoma (SCC) of the larynx and oropharyx. ## Methods Eighty patients with laryngeal (__n__ = 15) or oropharyngeal (__n__ = 65) SCC underwent concur

Clinical factors associated with outcome

Clinical factors associated with outcome in patients with metastatic clear-cell renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy

✍ Toni K. Choueiri; Jorge A. Garcia; Paul Elson; Mohamad Khasawneh; Saif Usman; Al 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 2 views

## Abstract ## BACKGROUND. Therapy targeted against the vascular endothelial growth factor (VEGF) pathway is a standard of care for patients with metastatic renal cell carcinoma (RCC). The identification of patients who are more likely to benefit from these agents is warranted. ## METHODS. In to

Squamous cell carcinoma of base of tongu

Squamous cell carcinoma of base of tongue in a patient with Fanconi's anemia treated with radiation therapy: Case report and review of literature

✍ Ashwini Budrukkar; Tanweer Shahid; Vedang Murthy; Tabish Hussain; Rita Mulherkar 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 341 KB 👁 2 views

## Abstract ## Background. Fanconi's anemia (FA) is a rare autosomal recessive genetic disorder characterized by congenital anomalies, progressive aplastic anemia, and a predisposition for malignancies. Solid tumors in the head and neck region, especially in the tongue, are rarely observed. Manage

Correlation of cervical carcinoma c-erb

Correlation of cervical carcinoma c-erb B-2 oncogene with cell proliferation parameters in patients treated with radiation therapy for cervical carcinoma

✍ Takashi Nakano; Kuniyuki Oka; Atsuko Ishikawa; Shinroku Morita 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB 👁 2 views

patients treated with radiation therapy. Prognosis was analyzed by CerbB-OPE, growth fraction determined with Ki-67 immunohistochemistry (Ki-GF), and the Division of Radiation Medicine, National Instimitotic index of proliferating cell population (pMI). tute of Radiological Sciences, Chiba, Japan.