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Concurrent chemotherapy with intensity-modulated radiation therapy for locally advanced squamous cell carcinoma of the larynx and oropharynx: A retrospective single-institution analysis

✍ Scribed by Nabil F. Saba; Scott Edelman; Mourad Tighiouart; Jennifer Gaultney; Lawrence W. Davis; Fadlo R. Khuri; Amy Chen; William Grist; Dong M. Shin

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 240 KB
Volume: 31
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21120

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✦ Synopsis

Abstract

Background

We present outcome data from concurrent chemotherapy and intensity‐modulated radiation therapy (IMRT) for squamous cell carcinoma (SCC) of the larynx and oropharyx.

Methods

Eighty patients with laryngeal (n = 15) or oropharyngeal (n = 65) SCC underwent concurrent IMRT and chemotherapy (cisplatin or carboplatin/paclitaxel).

Results

The 3‐year overall survival (OS) and disease‐free survival (DFS) were 81.2% and 78.3%, respectively, with a median follow‐up of 31.2 months. There was a statistically significant correlation between OS and DFS with N classification (p = .0001), but not with disease site or T classification. Toxicities compared favorably with prior reports using conventional radiation therapy.

Conclusions

This retrospective analysis reveals a very good outcome and an acceptable toxicity profile for patients with locally advanced SCC of the oropharynx and larynx treated with chemotherapy and IMRT concurrently. © 2009 Wiley Periodicals, Inc. Head Neck, 2009

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