Correlation of cervical carcinoma c-erb B-2 oncogene with cell proliferation parameters in patients treated with radiation therapy for cervical carcinoma
✍ Scribed by Takashi Nakano; Kuniyuki Oka; Atsuko Ishikawa; Shinroku Morita
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 205 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
patients treated with radiation therapy. Prognosis was analyzed by CerbB-OPE, growth fraction determined with Ki-67 immunohistochemistry (Ki-GF), and the Division of Radiation Medicine, National Instimitotic index of proliferating cell population (pMI). tute of Radiological Sciences, Chiba, Japan.
RESULTS.
CerbB-OPE was observed on the cell membrane of carcinoma cells. Positivity of CerbB-OPE, which was 42.4% in total, increased significantly with stage progression. No significant differences were observed among histologic subtypes.
Mean total Ki-GF and pMI were 36% and 2.5%, respectively. Mean Ki-GF for CerbB(/) patients was 26.2%, which was significantly lower than the 38.3% for CerbB(0) patients (P õ 0.01). The mean pMI for CerbB(/) patients was 3.7%, which was significantly higher than the 2% for CerbB(0) patients (P õ 0.05). The 5-year survival rates of CerbB(/) patients and CerbB(0) patients were 45.1% and 75.6%, respectively, indicating that CerbB(/) patients showed significantly poorer survival than CerbB(0) patients (P õ 0.01). The difference in survival was due mainly to local recurrence rather than distant metastasis. There were significant correlations between prognosis and Ki-GF and pMI.
CONCLUSIONS.
The poor prognosis of patients with cervical carcinoma with CerbB-OPE was due to local recurrences after radiation therapy. The correlations of CerbB-OPE with Ki-GF and pMI suggest that c-erb B-2 oncoprotein may play an important role in the cell proliferation status of cervical carcinoma.