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Facile synthesis of stable isotope-labeled antibacterial agent RWJ-416457 and its metabolite

✍ Scribed by Ronghui Lin; Larry E. Weaner

Book ID
112132931
Publisher
John Wiley and Sons
Year
2012
Tongue
French
Weight
323 KB
Volume
55
Category
Article
ISSN
0022-2135

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## Abstract Lamotrigine is a sodium channel antagonist used for the treatment of epilepsy. Synthesis of stable isotopically labelled (SIL) [M+7] versions of Lamotrigine **(1)** and its __N__‐methylated metabolite **(2)** are described. The routes to prepare these compounds used [M+5] labelled [^13^